Flow mechanics in thrombosis

Investigating the role of the mechanical environment

Platelet adhesion mechanics in high shear rate flows.

Mechanosensitive processes have a strong influence on the first stages of the thrombus formation. The adhesion of platelets, which occurs both in physiological hemostasis, as well as pathological thrombosis, is found to be highly shear dependent and sensitive to hydrodynamic alterations. The shift of initially even shear gradients, e.g. caused by a sudden reduction in vessel diameter (vasoconstriction), leads to the presence of so called elongational flows. These flow fields, defined by exerting tensile forces, are found to promote PLT adhesion under certain conditions, enabled by the mediation of prominent plasma molecule von Willebrand factor (vWF). Furthermore, PLT adhesion is known to depend on the presence of a CFL as well as the level of hematocrit.The effects of these essential blood flow parameters on PLT adhesion were investigated under static flow conditions, in straight geometries.



  1. Initial platelet aggregation in the complex shear environment of a punctured vessel model
    Christian J Spieker, Gábor Závodszky, Clarisse Mouriaux, and 2 more authors
    bioRxiv, 2023
  2. Simulating Initial Steps of Platelet Aggregate Formation in a Cellular Blood Flow Environment
    Christian J Spieker, Konstantinos Asteriou, and Gab́or Zav́odszky
    In International Conference on Computational Science, 2023


  1. Loss of \alpha4A-and \beta1-tubulins leads to severe platelet spherocytosis and strongly impairs hemostasis in mice
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    Blood, The Journal of the American Society of Hematology, 2022


  1. The effects of micro-vessel curvature induced elongational flows on platelet adhesion
    Christian J Spieker, Gábor Závodszky, Clarisse Mouriaux, and 4 more authors
    Annals of Biomedical Engineering, 2021