Problem
Early thrombus growth depends on local shear and transport, but aggregate microstructure is often simplified away in simulations. I investigated whether image-derived aggregate geometry and density significantly change local hemodynamic predictions.
Approach
- Reconstruct aggregate outline and internal density from microscopy experiments.
- Model aggregates as porous structures with permeability informed by microstructure.
- Simulate flow and transport under multiple imposed wall shear rates.
- Quantify shear, elongation, kinetic force, and local Péclet behavior inside and around aggregates.
Key finding
Both shear rate and aggregate microstructure strongly affected local transport and mechanical loading. Transition zones between shell and core showed pronounced force signatures relevant to structural interpretation.
Why it matters
Including experimentally informed microstructure improves mechanistic understanding of how flow shapes thrombus initiation and evolution.
Outputs
- Publication details are listed in the References section below.
- Representative reconstruction and simulation visuals are included on this page.